MOD-02 · Cell Fate Metro Map

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hPSC Differentiation Pathways · Fig. 01
ENDODERM DERIVATIVESMESODERM DERIVATIVESGERM CELLSECTODERM DERIVATIVES · NEURALECTODERM DERIVATIVES · SURFACEActivin A + CHIRActivin A 100Noggin + SB431542CHIR + FGF10 + RABMP4 + FGF2HGF + OSMKGF + RA + SANT-1ALK5i + T3 + GSICHIR + FGF4R-spo + Noggin + EGFCHIR 6–12 µMBMP4 highVEGF + FGF2IWP2 (Wnt off)B-27CHIR + LDNSAG (SHH)CHIR + FGF2CHIR + ActivinFGF9 + heparinCHIR pulseActivin A + CHIRBMP4 + SCF + LIFrOvary co-cultureDual-SMADFGF2 + EGFMatrigel embedSHH agonistBDNF + DAPTSHH + CHIRPDGF-AACNTFT3 + IGF-1BMP4 + SB431542FGF2 + LDNEGF + Ca²⁺FGF2 + Wnt3aD0hPSCOCT4 / NANOG / SOX2D1Primitive StreakTBXT / MIXL1 / EOMESD3Definitive EndodermSOX17 / FOXA2D6Anterior ForegutSOX2 / FOXA2D15Lung ProgenitorsNKX2-1 / SOX9D8Hepatic ProgenitorsHNF4A / PROX1 / AFPD20HepatocytesALB / HNF1AD12Pancreatic ProgenitorsPDX1 / NKX6-1D27β-like CellsINS / MAFA / NKX6-1D7Hindgut EndodermCDX2 / SOX9D28Intestinal OrganoidsCDX2 / LGR5 / VIL1D2Mesoderm ProgenitorTBXT / MIXL1 / MESP1D3Lateral Plate MesodermHAND1 / FOXF1D5HemangioblastsETV2 / TAL1 / RUNX1D4Cardiac MesodermMESP1 / ISL1 / GATA4D10CardiomyocytesNKX2-5 / TBX5 / MYH6D3Paraxial MesodermTBX6 / MSGN1D7SclerotomePAX1 / SOX9 / NKX3-2D12MyotomePAX3 / PAX7 / MYOD1D4Intermediate MesodermOSR1 / PAX2 / LHX1D9Renal ProgenitorsSIX2 / PAX2 / WT1D21Kidney OrganoidPAX2 / WT1 / PODXLD2iMeLCTBXT / EOMESD6PGCLCSOX17 / BLIMP1 / TFAP2CD120Oogonia-likeDAZL / DDX4D6Neural EctodermPAX6 / SOX1 / OTX2D12Neural ProgenitorsSOX2 / NES / PAX6D30Radial GliaFOXG1 / PAX6 / HOPXD45GABAergic NeuronsDLX2 / GAD67D45Glutamatergic NeuronsTBR1 / CTIP2 / SATB2D35Dopaminergic NeuronsFOXA2 / LMX1A / THD60Glial ProgenitorsOLIG2 / NFIA / SOX9D90AstrocytesGFAP / S100BD100OligodendrocytesSOX10 / MBPD4Surface EctodermTFAP2A / KRT8/18D8Outer EctodermTP63 / KRT5D30EpidermisKRT14 / KRT10 / IVLD35Lens / CorneaPAX6 / PROX1 / KRT12
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